The Food Environment, Microbial Cysteine Metabolism, and Cancer Disparities

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to learn if changing cysteine levels in the diet can influence how the body processes cysteine in Black and White individuals aged 45-75 with a history of non-cancerous polyps. The main questions it aims to answer are: * At the beginning of the study, do Black participants have higher levels of cortisol (a stress hormone) and compounds made from cysteine in their blood when compared to White participants? * Does eating less cysteine lower the body's natural cysteine activity and lead to less gut bacteria that break down cysteine? * Does eating less cysteine lead to less inflammation in the gut and lower levels of markers of inflammation in the blood? Research will compare a high cysteine diet and a low cysteine diet, and each participant will eat both diets. Participants will be in the study for 11 weeks and 2 days. Over the course of the study, participants will: * Eat a high cysteine diet for 3 weeks, and a low cysteine diet for 3 weeks * Eat a moderate cysteine diet for 1 week before each study diet * Complete surveys * Provide blood, stool, and saliva samples * Maintain food logs

Eligibility
Participation Requirements
Sex: All
Minimum Age: 45
Maximum Age: 75
Healthy Volunteers: f
View:

• Aged 45-75

• Up to date with CRC screening colonoscopy with a high risk of CRC, defined as a history of 3 or more adenomatous polyps (APs) or an AP \>1 cm in the past 5 years

• Identify as Black or Non-Hispanic White

• If female, no menstrual period for at least six months

• Willingness to donate oral wash and stool samples

• Willingness to complete 24-hour dietary recalls

Locations
United States
Indiana
University Hospital Clinical Research Center
NOT_YET_RECRUITING
Indianapolis
Purdue Clinical Research Center
RECRUITING
West Lafayette
Contact Information
Primary
Patricia G Wolf, PhD, RD
wolfpm@purdue.edu
765-494-1860
Time Frame
Start Date: 2025-07-30
Estimated Completion Date: 2027-08-01
Participants
Target number of participants: 40
Treatments
Experimental: High cysteine diet
Participants will eat a diet higher in cysteine, relying on more animal based protein.
Experimental: Low cysteine diet
Participants will eat a diet lower in cysteine, relying on more plant based protein.
Related Therapeutic Areas
Sponsors
Collaborators: Indiana University, American Cancer Society, Inc.
Leads: Purdue University

This content was sourced from clinicaltrials.gov